Abstract
Trifluoromethyl groups are of great interest in PET radiopharmaceuticals. Radiolabelled 4-aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases. Here, we describe methods for producing (11)C-trifluoromethylated derivatives of 4AP and present early imaging results with [(11)C]3-trifluoromethyl-4AP in a rhesus macaque. This study shows the utility of [(11)C]CuCF(3) for labelling pyridines and provides initial evidence for the potential use of [(11)C]3-trifluoromethyl-4AP as a PET radioligand.