A Case of Trisomy 9 Mosaicism Diagnosed Following Detection of Placental Trisomy 9

一例在检测到胎盘9号染色体三体综合征后确诊的9号染色体三体嵌合体病例

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Abstract

We report a case in which fetal growth restriction was observed during pregnancy. A placental chromosomal analysis was performed to investigate the cause of the fetal growth restriction and it showed trisomy 9. Prompt chromosomal testing of the neonate led to the diagnosis of trisomy 9 mosaicism. Although the neonate was small for gestational age and had mild respiratory distress and feeding difficulties, her clinical symptoms were minimal. Trisomy 9 mosaicism is extremely rare and shows considerable variability in its clinical presentation. This case report is important because trisomy 9 was detected by a placental chromosome analysis that was conducted to investigate the cause of fetal growth restriction. Additionally, a newborn with mild clinical findings was unexpectedly diagnosed with trisomy 9 mosaicism.

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