Cyclobutenone as a highly reactive dienophile: expanding upon Diels-Alder paradigms

环丁烯酮作为一种高活性亲二烯体:拓展狄尔斯-阿尔德反应范式

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Abstract

Cyclobutenone was employed as a dienophile in Diels-Alder cycloadditions, provide diverse and complex cycloadducts in good yields. Experimental outcomes indicated cyclobutenone to be more reactive than either cyclopentenone or cyclohexenone. In addition, cycloadducts bearing a strained cyclobutanone moiety were able to undergo regioselective ring expansions to produce corresponding cyclopentanones, lactones, and lactams, which are otherwise difficultly obtained by direct Diels-Alder reactions.

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