Abstract
This article describes free radical scavenging activity of TEMPO (2, 2, 6, 6-tetramethylpiperidin-1-yloxyl) radical functionalized dendrimers of generation G0 - G4 against nitric oxide (NO), 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide (H(2)O(2)) radicals. The total antioxidant activity of the dendrimers was also reported and compared with pure 4-hydoxy TEMPO (constituent of dendrimers) and ascorbic acid (vitamin C) standard. The activity of TEMPO functionalized G4 dendrimer against scavenging of nitric oxide and hydrogen peroxide radicals was found comparable to vitamin C. The data presented in this article supports the good antioxidant activity of the dendrimers newly reported in our previous publication (Radical dendrimers: Synthesis, anti-tumor activity and enhanced cytoprotective performance of TEMPO free radical functionalized polyurethane dendrimers).