Abstract
The data herein presented show multivariate linear regressions performed to examine the association between individual serum perfluoroalkyl acids (PFAAs) [perfluorooctane sulfonic acid (PFOS); linear form of perfluorooctanoic acid (PFOA); perfluorohexane sulfonic acid (PFHxS); perfluorononanoic acid (PFNA)], and biomarkers of liver function (Sex Differences in the association between perfluoroalkyl compounds and liver function in US adolescents: analyses of NHANES 2013-2016). Data relate to male and female adolescents (ages 12-19 years) who participated to the 2013-2016 National Health and Nutrition Examination Survey. The outcome of interest was represented by changes in biomarkers of liver function, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). Serum measurement values of ALT, AST and GGT were natural log-transformed. Data represent multivariate regression analyses with the single PFAA as β coefficients (and 95%CI), adjusted by age, race/ethnicity, body weight, education, income-to-poverty ratio, and exposure to smoking. Single PFAAs were used as continuous natural log-transformed predicted variables in males and females. Analyses were performed also with individuals PFAAs categorized via sex-specific weighted quartile, with cutoffs based on the weighted distribution of the single PFAA in the study population. Because the dependent variables (ALT, AST and GGT) were log-transformed, data were re-transformed by exponentiation of the β coefficients, and presented as percent differences estimated by comparing each of the upper three quartiles to the lowest quartile using the formula 100*(e(β) -1). Together, these data can serve as a basis to analyze associations between liver function and PFAA exposure taking into account sex differences in adolescent populations.