In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

深入的免疫表型分析数据表明,IL-17Ab能够调节循环中的Treg/Th17细胞以及痛风炎症发作时原位浸润的炎症性单核细胞。

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Abstract

The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4(+)CD25(+)Foxp3(+)), Th17 (defined as CD4(+)IL-17(+)) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220(-)GR1(high)F480(high)CD115(+)).

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