Abstract
Chalcone-linked acetamide derivatives represent a unique class of compounds with a broad spectrum of biological activities. Various synthetic methods for chalcones are reviewed, emphasizing their efficiency. These derivatives exhibited potent antiproliferative properties, functioning as inhibitors of key targets such as EGFR, topoisomerase I and II, ABCG2, caspase proteins, and histone deacetylase (HDAC), as well as inhibiting tubulin polymerization. The structure-activity relationships (SAR) pertinent to their anticancer activity are elucidated. In addition to their antiproliferative effects, these compounds display significant antimicrobial activities against a variety of bacterial and fungal pathogens. Their antiviral potential is also highlighted, with capabilities to inhibit critical viral enzymes and pathways. The antiprotozoal properties of chalcone-linked acetamide derivatives underscore their efficacy against protozoan infections. Furthermore, these derivatives possess strong anti-inflammatory and antioxidant activities, contributing to their overall therapeutic potential. By exploring these diverse biological activities, these compounds present significant opportunities for the development of novel therapeutic agents overcoming various medical challenges.