Abstract
Endosulfan, a persistent organochlorine pesticide, has raised global concern due to its toxicological effects on human health and the environment. The popularity of endosulfan was driven by its effectiveness and low cost compared to alternative insecticides. The compound's environmental persistence and bioaccumulative properties also contributed to its sustained use over several decades. Despite regulatory bans in many countries, residues of endosulfan continue to be detected in soil, water, and food sources, posing a threat through chronic exposure. Although endosulfan has been listed in the Stockholm Convention as a persistent organic pollutant targeted for global elimination, it is still used illegally in some countries. This mini-review synthesizes current knowledge on its toxicological profile, including neurotoxicity, endocrine disruption, reproductive toxicity, potential carcinogenicity, and acute poisoning, based on the latest scientific literature. The paper also highlights current regulatory frameworks, historical usage trends, global distribution and alternatives to endosulfan in agriculture. Understanding the scope of its health impacts and ongoing risks is crucial for policymakers, researchers, and public health authorities seeking to protect populations from legacy pollutants. In addition, recognizing the long-term impacts of endosulfan is essential for effective health risk assessment, environmental monitoring, and the promotion of safer alternatives.