Abstract
BACKGROUND: Patients with ovarian cancer often experience significant psychological stress during chemotherapy, including emotional disorders such as anxiety and depression. AIM: To analyze the application value of positive emotion, engagement, relationships, meaning, and accomplishment (PERMA) well-being care combined with role model motivation in patients with ovarian cancer undergoing chemotherapy for anxiety and depression, with a focus on psychological health and compliance behavior. METHODS: Seventy patients with ovarian cancer undergoing chemotherapy were recruited from a hospital between August 2022 and August 2024. They were randomly divided into two groups using a lottery method: The reference group (n = 35, receiving routine care) and the experimental group (n = 35, receiving PERMA well-being care combined with role model motivation in addition to routine care). Both groups received their respective interventions before and after chemotherapy. Psychological state, mood state, compliance behavior, and cancer-related fatigue levels were assessed before and after the intervention. Data were analyzed using the SPSS software (version 26.0). RESULTS: After the intervention, patients' psychological state improved, with the experimental group showing greater benefits than the control group. Specifically, the intervention group achieved an 8.8% reduction in anxiety, a 19.8% reduction in depressive symptoms, and a 7.8% increase in self-efficacy relative to controls (P < 0.05). Mood state also improved more markedly in the experimental group, with significant reductions across tension-anxiety, depression-dejection, anger-hostility, fatigue-inertia, and confusion-bewilderment, alongside an increase in vigor-activity (P < 0.05). The compliance rate was higher in the experimental group than in the control group (91.43% vs 71.43%, P < 0.05). Cancer-related fatigue decreased in both groups, with the experimental group exhibiting greater reductions across emotional, cognitive, behavioral, and physical dimensions (P < 0.05). CONCLUSION: PERMA well-being care combined with role model motivation is effective in reducing anxiety and depression symptoms, improving mood states, enhancing compliance behavior, and alleviating cancer-related fatigue in patients with ovarian cancer undergoing chemotherapy for anxiety and depression. Therefore, this approach warrants broader clinical application.