Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT(2A)R, 5-HT(2B)R and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT(2A)R and 5-HT(2B)R and one compound showed a higher selectivity towards 5-HT(2A)R than psilocin.