Background
Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The
Conclusion
Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
Methods
Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.
Results
Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.