Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function

砷靶向 PML-RARA 癌蛋白的结构基础揭示了控制 PML 体组装和功能的半胱氨酸变阻器

阅读：5

作者：Pierre Bercier #, Qian Qian Wang #, Ning Zang, Jie Zhang #, Chang Yang, Yasen Maimaitiyiming, Majdouline Abou-Ghali, Caroline Berthier, Chengchen Wu, Michiko Niwa-Kawakita, Thassadite Dirami, Marie-Claude Geoffroy, Omar Ferhi, Samuel Quentin, Shirine Benhenda, Yasumitsu Ogra, Zoher Gueroui, Chun Zho

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2023

起止号：

2023 Dec 12;13(12):2548-2565.

doi：

10.1158/2159-8290.CD-23-0453

种属：

Goat

方法学：

IHC

靶点：

IgG Fc

研究方向：

肿瘤

Significance

Arsenic curative effects in APL rely on PML targeting. We report a PML B-box-2 structure that drives trimer assembly, positioning a cysteine trio to form an arsenic-binding pocket, which is disrupted in resistant patients. Identification of this ROS-sensitive triad controlling PML dynamics and functions could yield novel drugs. See related commentary by Salomoni, p. 2505. This article is featured in Selected Articles from This Issue, p. 2489.

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