Abstract
Background/Objectives: This paper is significant in highlighting the importance of early and precise diagnosis of Parkinson's Disease (PD) that affects both motor and non-motor functions to achieve better disease control and patient outcomes. This study seeks to assess the effectiveness of machine learning algorithms optimized to classify PD based on vocal characteristics to serve as a non-invasive and easily accessible diagnostic tool. Methods: This study used a publicly available dataset of vocal samples from 188 people with PD and 64 controls. Acoustic features like baseline characteristics, time-frequency components, Mel Frequency Cepstral Coefficients (MFCCs), and wavelet transform-based metrics were extracted and analyzed. The Chi-Square test was used for feature selection to determine the most important attributes that enhanced the accuracy of the classification. Six different machine learning classifiers, namely SVM, k-NN, DT, NN, Ensemble and Stacking models, were developed and optimized via Bayesian Optimization (BO), Grid Search (GS) and Random Search (RS). Accuracy, precision, recall, F1-score and AUC-ROC were used for evaluation. Results: It has been found that Stacking models, especially those fine-tuned via Grid Search, yielded the best performance with 92.07% accuracy and an F1-score of 0.95. In addition to that, the choice of relevant vocal features, in conjunction with the Chi-Square feature selection method, greatly enhanced the computational efficiency and classification performance. Conclusions: This study highlights the potential of combining advanced feature selection techniques with hyperparameter optimization strategies to enhance machine learning-based PD diagnosis using vocal characteristics. Ensemble models proved particularly effective in handling complex datasets, demonstrating robust diagnostic performance. Future research may focus on deep learning approaches and temporal feature integration to further improve diagnostic accuracy and scalability for clinical applications.