Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA
酵母转录辅激活因子 Sub1 及其人类同源物 PC4 优先与 G-四链体 DNA 结合
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作者：Jun Gao, Boris L Zybailov, Alicia K Byrd, Wezley C Griffin, Shubeena Chib, Samuel G Mackintosh, Alan J Tackett, Kevin D Raney
Abstract
Using a G-quadruplex bait, we identified the transcription co-activator Sub1 as a G-quadruplex binding protein by quantitative LC-MS/MS and demonstrated in vivo G-quadruplex binding by ChIP. In vitro, Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes. This provides a possible mechanism by which G-quadruplexes can influence gene transcription.
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