Abstract
BACKGROUND: Cervical radiculopathy is a common cause of pain. For patients who fail conservative management, a transforaminal epidural steroid injection (TFESI) is an accepted intervention and alternative to decompression surgery. OBJECTIVE: The purpose of this study was to evaluate the therapeutic effect of TFESIs for patients with cervical radiculopathy. METHODS: Adult patients treated at a multidisciplinary, tertiary academic spine center with cervical radicular pain and MRI evidence of corroborative cervical spondylotic foraminal stenosis and who had failed at least 6 weeks of conservative management consisting of medication and physical rehabilitation were included in this study. Patient Reported Outcome Measurement Information System (PROMIS) domains of Physical Function (PF) v1.2/v2.0 and Pain Interference (PI) v1.1 were collected at baseline and at 3-, 6-, and 12-month follow-up visits. Statistical analysis comparing baseline score with follow-up post-procedural PROMIS scores was performed. The percentage of patients who reported improvement exceeding the minimal clinically important difference was calculated for survey responders and for the worst case scenario. RESULTS: 87 patients met inclusion criteria. PROMIS PI at 3-, 6-, and 12-months follow-up statistically improved by 2.2 (95 % confidence interval [CI] 2.1-2.4, p = 0.02), 2.3 (95 % CI 2.1-2.5, p = 0.03), and 2.7 (95 % CI 2.5-3.0, p = 0.03) points, respectively. Follow-up PROMIS PF score did not significantly differ from baseline scores. The percentage of patients that exceeded MCID thresholds of clinical significance was 59 % (95 % CI 47%-70 %) at 3-months, 52 % (95 % CI 41%-63 %) at 6-months, and 60 % (95 % CI 50%-72 %) at 12-months. Worst case scenario analysis demonstrated that 51 % (95 % CI 39%-62 %) of patients exceeded the MCID thresholds at 3-months, 32 % (95 % CI 22%-43 %) at 6-months, and 23 % (95 % CI 13%-33 %) at 12-months. CONCLUSIONS: Our study demonstrated that TFESI leads to a long-term improvement up to a year in pain for patients with cervical radiculopathy.