Fibroblasts and macrophages of mice with the Chediak-Higashi-like syndrome have microtubules and actin cables

患有切迪亚克-希加西样综合征的小鼠的成纤维细胞和巨噬细胞中含有微管和肌动蛋白丝。

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Abstract

Cells of the beige mouse contain abnormally large lysosomes and show enhanced capping of concanavalin A. It has been suggested that these phenomena may be secondary to a defect in microtubule polymerization. We have examined the cytoskeleton of beige mouse cells by indirect immunofluorescence and find the number and distribution of microtubules and actin cables to be indistinguishable from those of normal control cells.

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