Background
Laminin subunit beta 1 (LAMB1) has regulatory functions on the proliferation, attachment, and migration of tumor cells, with increased levels linked to different cancers.
Conclusions
LAMB1 downregulation exerted antitumor effects on glioma cells by regulating the NF-κB/HK2 axis.
Objective
This study aims at investigating the effects and mechanisms of LAMB1 in glioma.
Results
LAMB1 overexpression enhanced cell viability, proliferation, and invasion and promoted glioma cell growth. LAMB1 upregulation enhanced cellular glycolysis and repressed the sensitivity of cells to TMZ. LAMB1 activated the NF-κB pathway. Downregulation of LAMB1 or mitigating of the NF-κB pathway by Bay 11-7082 inhibited glioma cell proliferation, growth, and glycolysis and enhanced TMZ sensitivity. Conclusions: LAMB1 downregulation exerted antitumor effects on glioma cells by regulating the NF-κB/HK2 axis.