Abstract
BACKGROUND: Gastric metastasis from melanoma is rare and often presents as an unexpected finding, rarely revealing an underlying primary skin melanoma. CASE PRESENTATION: We report a case of a 62-year-old male who presented with abdominal pain, dyspepsia, anorexia, and weight loss. On physical examination abdominal masses and hepatomegaly were detected. Radiological imaging showed widespread masses in the abdominal and thoracic regions. Upper gastrointestinal endoscopy identified an umbilicated protruded lesion with central dark pigmentation at the antro-fundic junction. Histopathological examination and immunohistochemical staining were consistent with melanoma. A subsequent rigorous skin examination uncovered a primary malignant skin melanoma. Due to worsening general condition, the patient received palliative hospice care. CONCLUSION: This report highlights the critical need for vigilant skin examination when dealing with widespread metastatic disease.