Abstract
To try to determine whether fluid therapy during surgery should be on a large or a small scale 23 patients and six control subjects were studied. The control subjects were fasted and transfused with 2 litres of Ringer-lactate solution in one hour, the volume of urine output being measured at intervals for four hours. The patients were transfused similarly under varying conditions of anaesthesia and surgery. The characteristic urine output during abdominal hysterectomy followed a low, irregular pattern, and this occurred whether or not substantial amounts of fluid were transfused. In two patients anaesthesia and minimal trauma were associated with oliguria. An established diuresis was altered by anaesthesia and inhibited by surgery. These results indicate that excess Ringer-lactate solution administered during surgery may not be excreted and that overtransfusion could easily occur.