Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus

用淋巴细胞性脉络丛脑膜炎病毒假型化的逆转录病毒载体

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Abstract

Pseudotyping can improve retroviral vector stability and transduction efficiency. Here, we describe a novel pseudotype of murine leukemia virus packaged with lymphocytic choriomeningitis virus (LCMV). This pseudotype was stable during ultracentrifugation and infected several cell lines from different species. Moreover, LCMV glycoproteins were not cell toxic.

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