Abstract
The analysis of high-dimensional microarray gene expression data presents critical challenges, including excessive dimensionality, increased computational burden, and sensitivity to random initialization. Traditional optimization algorithms often produce inconsistent and suboptimal results, while failing to preserve local data structures limiting both predictive accuracy and biological interpretability. To address these limitations, this study proposes an adaptive neighborhood-preserving multi-objective particle swarm optimization (ANPMOPSO) framework for gene selection. ANPMOPSO introduces four key innovations: (1) a weighted neighborhood-preserving ensemble embedding (WNPEE) technique for dimensionality reduction that retains local structure; (2) Sobol sequence (SS) initialization to enhance population diversity and convergence stability; (3) a differential evolution (DE)-based adaptive velocity update to dynamically balance exploration and exploitation; and (4) a novel ranking strategy that combines Pareto dominance with neighborhood preservation quality to prioritize biologically meaningful gene subsets. Experimental evaluations on six benchmark microarray datasets and eleven multi-modal test functions (MMFs) demonstrate that ANPMOPSO consistently outperforms state-of-the-art methods. For example, it achieves 100% classification accuracy on Leukemia and Small-Round-Blue-Cell Tumor (SRBCT) using only 3-5 genes, improving accuracy by 5-15% over competitors while reducing gene subsets by 40-60%. Additionally, on MMFs, ANPMOPSO attains superior hypervolume values (e.g., 1.0617 ± 0.2225 on MMF1, approximately 10-20% higher than competitors), confirming its robustness in balancing convergence and diversity. Although the method incurs higher training time due to its structural and adaptive components, it achieves a strong trade-off between computational cost and biological relevance, making it a promising tool for high-dimensional gene selection in bioinformatics.