Abstract
This prospective study explored the application of texture features extracted from T2WI and apparent diffusion coefficient (ADC) maps in predicting recurrence of advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). We included 34 patients with advanced cervical cancer who underwent pelvic MR imaging before, during and after CCRT. Radiomic feature extraction was performed by using software at T2WI and ADC maps. The performance of texture parameters in predicting recurrence was evaluated. After a median follow-up of 31 months, eleven patients (32.4%) had recurrence. At four weeks after CCRT initiated, the most textural parameters (four T2 textural parameters and two ADC textural parameters) showed significant difference between the recurrence and nonrecurrence group (P values range, 0.002~0.046). Among them, RunLengthNonuniformity (RLN) from T2 and energy from ADC maps were the best selected predictors and together yield an AUC of 0.885. The support vector machine (SVM) classifier using ADC textural parameters performed best in predicting recurrence, while combining T2 textural parameters may add little value in prognosis. T2 and ADC textural parameters have potential as non-invasive imaging biomarkers in early predicting recurrence in advanced cervical cancer treated with CCRT.