Abstract
BACKGROUND: Lymph node (LN) metastasis is an important factor affecting the treatment of lung cancer. The purpose of this article was to investigate the benefits of dual-layer spectral detector computed tomography (SDCT) for the evaluation of metastatic LNs in lung cancer. METHODS: Data from 93 patients with lung cancer who underwent dual-phase enhanced scanning with SDCT were retrospectively analyzed. According to the pathological findings, 166 LNs were grouped as metastatic (n=80) or non-metastatic (n=86). LNs in station 4 (n=80) and station 7 (n=35) accounted for the majority of the LNs (approximately 69.23%). The short-axis diameter of the LN, arterial enhancement fraction (AEF), normalized iodine concentration (NIC), and the slope of the spectral Hounsfield unit curve (λ(HU)) during the arterial phase (AP) and venous phase (VP) were measured. The Mann-Whitney U test was used to statistically compare these quantitative parameters. Receiver operating characteristic (ROC) curves were plotted to identify the cutoff values, and decision curve analysis (DCA) was performed to determine the net benefit of each parameter. The diagnostic performance, obtained by combining the short-axis diameter with each of the above parameters, was also studied. RESULTS: The short-axis LN diameter, AEF, NIC, and λ(HU) during the AP and VP all showed significant differences between the metastatic and non-metastatic groups (P<0.05). Of the parameters, the AEF had the greatest diagnostic efficiency for metastatic LNs [area under the ROC curve (AUC)(AEF) =0.885] with a threshold of 86.40%. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and 95% confidence interval were 90.00%, 89.53%, 88.89%, 90.59%, and 0.830-0.944, respectively. When the quantitative parameters were combined with the short-axis diameter, the AUCs of the parameters, except the AEF, were significantly improved (P<0.05). CONCLUSIONS: The iodine quantitative parameters from SDCT, such as the AEF, demonstrated high diagnostic performances in the differentiation of metastatic and non-metastatic LNs.