Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells

铁蛋白通过大鼠肝星状细胞中铁非依赖性蛋白激酶 C zeta/核因子 κB 调节信号发挥促炎细胞因子的作用

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作者:Richard G Ruddell, Diem Hoang-Le, Joanne M Barwood, Paul S Rutherford, Terrance J Piva, Dianne J Watters, Paolo Santambrogio, Paolo Arosio, Grant A Ramm

Conclusions

This study has defined the role of ferritin as a proinflammatory mediator of hepatic stellate cell biology acting through the NF-kappaB signaling pathway, and suggests a potential role in the inflammatory processes associated with hepatic fibrogenesis.

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