Abstract
INTRODUCTION: Parkinson's disease (PD) is characterized by muscle stiffness, bradykinesia, and balance disorders, significantly impairing the quality of life for affected patients. While motion pose estimation and gait analysis can aid in early diagnosis and timely intervention, clinical practice currently lacks objective and accurate tools for gait analysis. METHODS: This study proposes a multi-level 3D pose estimation framework for PD patients, integrating monocular video with Transformer and Graph Convolutional Network (GCN) techniques. Gait temporal and spatial parameters were extracted and verified for 59 healthy elderly and PD patients, and an early prediction model for PD patients was established. RESULTS: The repeatability of the gait parameters showed strong consistency, with most of the estimated parameters yielding an Intraclass Correlation Coefficient (ICC) greater than 0.70. Furthermore, these parameters exhibited a high correlation with VICON and ATMI results (r > 0.80). The classification model based on the extracted parameter features, using a Random Forest (RF) classifier, achieved an accuracy of 93.3%. CONCLUSION: The proposed 3D pose estimation method demonstrates high reliability and effectiveness in providing accurate 3D human pose parameters, with strong potential for early prediction of PD. SIGNIFICANCE: This markerless method offers significant advantages in terms of low cost, portability, and ease of use, positioning it as a promising tool for monitoring and screening PD patients in clinical settings.