Abstract
PURPOSE: To explore the impact of macular ischaemia on vision in diabetic macular oedema (DMO) by analysing the correlations between visual acuity and macular microvascular parameters using optical coherence tomography angiography (OCTA). METHODS: OCTA was performed in 81 eyes of 48 patients with DMO, and 3 × 3-mm(2) en face OCTA images of the superficial capillary plexus and deep capillary plexus in the central macula were retrospectively collected. Microvascular parameters including the number of microaneurysms, area of foveal avascular zone (FAZ), acircularity index of FAZ, vessel density, skeleton density, vessel density index and fractal dimension were measured. Central retinal thickness (CRT) and the presence of ellipsoid zone disruption at the fovea were also recorded. Linear mixed models were used to evaluate the correlations between best-corrected visual acuity (BCVA) and the microvascular parameters. RESULTS: After adjustment for CRT and ellipsoid zone disruption at the fovea, lower skeleton density and lower fractal dimension in the deep capillary plexus were correlated with poorer BCVA (P = 0.030 and 0.024, respectively). None of the microvascular parameters of the superficial capillary plexus were correlated with BCVA after adjustment for CRT and ellipsoid zone disruption (all, P > 0.05). CONCLUSIONS: For eyes with DMO, low skeleton density and low branching complexity in the deep capillary plexus of central macula were correlated with poor vision. OCTA could offer quantified parameters of macular microvasculature to measure the impact of macular ischaemia on visual acuity in DMO.