Abstract
OBJECTIVES: To compare the expression levels of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-16, and IL-18 in gingival crevicular fluid between patients with invisible orthodontics treatment and fixed orthodontics treatment. METHODS: A total of 67 patients with invisible orthodontic treatment were selected as the observation group, and 40 patients with fixed orthodontic treatment were selected as the control group. The expression levels of IL-1β, IL-6, IL-8, IL-10, IL-16, and IL-18 in gingival crevicular fluid before, 24 h, and 12 months after orthodontic treatment were detected. RESULTS: No significant difference in basic characteristics and interleukin expression levels in gingival crevicular fluid was observed between the two groups before orthodontic treatment (P>0.05). After 24 h of orthodontic treatment, the expression levels of IL-1β, IL-6, IL-8, IL-10, and IL-18 in gingival crevicular fluid increased in both groups; however, no significant difference was observed between the two groups (P>0.05). After 12 months of orthodontic treatment, the expression levels of IL-1β, IL-6, IL-8, IL-10, and IL-18 in gingival crevicular fluid in the observation group were significantly lower than those in the control group (P<0.05), and no significant difference in the expression level of IL-16 was observed between the two groups (P>0.05). CONCLUSIONS: Compared with patients with fixed orthodontics treatment, those with invisible orthodontics treatment had weaker oral inflammatory response, which was conducive to the recovery of the oral microenvironment.