Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite

利用胶原蛋白-血小板复合材料进行骨间固定可增强猪前交叉韧带的功能性愈合。

阅读:1

Abstract

PURPOSE: The purpose of this study was to determine whether providing bony stabilization between the tibia and femur improves the structural properties of an "enhanced" anterior cruciate ligament (ACL) repair using a collagen-platelet composite when compared with the traditional (Marshall) suture technique. METHODS: Twelve pigs underwent unilateral ACL transection and were treated with sutures connecting the bony femoral ACL attachment site to the distal ACL stump (ligament group) or to the tibia through a bone tunnel (tibia group). A collagen-platelet composite was placed around the sutures to enhance the biological repair in both groups. Anteroposterior knee laxity and the graft structural properties were measured after 15 weeks of healing in both the ACL-repaired and contralateral, ACL-intact joints. RESULTS: Enhanced ACL repair with bone-to-bone fixation significantly improved yield load and linear stiffness of the ACL repairs (P < .05) after 15 weeks of healing. However, laxity values of the knees were similar in both groups of repaired knees (P > .10). CONCLUSIONS: Using an enhanced ACL suture repair technique that includes bone-to-bone fixation to protect the repair in the initial healing stages resulted in an ACL with improved structural properties after 15 weeks in the porcine model. CLINICAL RELEVANCE: The healing response of an ACL suture repair by use of a collagen-platelet composite can be enhanced by providing bony stabilization between the tibia and femur to protect the graft during the initial healing process in a translational model.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。