Abstract
OBJECTIVE: This study investigated the relationship between serum magnesium, phosphorus, and calcium and low-gradient severe aortic stenosis (LG-AS). METHODS: Dobutamine stress echocardiography (DSE) and resting echocardiography were performed on 73 patients with LG-AS. A projected aortic valve area (AVA(proj)) ≤ 1 cm(2) or indexed AVAI(proj) < 0.60 cm(2)/m(2) was defined as true-severe AS. Serum magnesium, phosphorus, and calcium were compared. The correlation between serum micronutrients and resting echocardiographic parameters was analyzed. The efficacy of serum micronutrients and resting echocardiographic parameters in predicting true-severe AS in LG-AS was assessed. RESULTS: DSE diagnosed true-severe AS in 43 patients and pseudo-severe AS in 30 patients. AVA and AVAI were smaller, and the mean pressure gradient (PG) was higher in patients with true-severe AS. Serum calcium and phosphorus were higher, and serum magnesium was lower in patients with true-severe AS. Serum calcium was positively correlated with AVA and AVAI. Serum magnesium had a moderately strong correlation with mean PG. Serum micronutrients had good predictive value for true-severe AS and AVAI, and mean PG improved the predictive value of serum micronutrients. CONCLUSION: Serum micronutrients have diagnostic values for true-severe AS in patients with LG-AS.