A human monoclonal antibody blocking SARS-CoV-2 infection

阻断 SARS-CoV-2 感染的人类单克隆抗体

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作者:Chunyan Wang #, Wentao Li #, Dubravka Drabek #, Nisreen M A Okba, Rien van Haperen, Albert D M E Osterhaus, Frank J M van Kuppeveld, Bart L Haagmans, Frank Grosveld, Berend-Jan Bosch

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

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