Abstract
The essential interaction between Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) and basigin makes RH5 a prime target for broadly neutralizing antibodies. A recent study by Barrett et al. mapped the RH5 antigenic landscape from RH5.1/AS01(B) vaccinees and identified a potent public antibody clonotype, advancing malaria vaccine and prophylactic antibody development.