The DNA sequence and analysis of human chromosome 13

人类13号染色体的DNA序列及分析

阅读：1
作者：Dunham,A,Matthews,L H,Burton,J,Ashurst,J L,Howe,K L,Ashcroft,K J,Beare,D M,Burford,D C,Hunt,S E,Griffiths-Jones,S,Jones,M C,Keenan,S J,Oliver,K,Scott,C E,Ainscough,R,Almeida,J P,Ambrose,K D,Andrews,D T,Ashwell,R I S,Babbage,A K,Bagguley,C L,Bailey,J,Bannerjee,R,Barlow,K F,Bates,K,Beasley,H,Bird,C P,Bray-Allen,S,Brown,A J,Brown,J Y,Burrill,W,Carder,C,Carter,N P,Chapman,J C,Clamp,M E,Clark,S Y,Clarke,G,Clee,C M,Clegg,S C M,Cobley,V,Collins,J E,Corby,N,Coville,G J,Deloukas,P,Dhami,P,Dunham,I,Dunn,M,Earthrowl,M E,Ellington,A G,Faulkner,L,Frankish,A G,Frankland,J,French,L,Garner,P,Garnett,J,Gilbert,J G R,Gilson,C J,Ghori,J,Grafham,D V,Gribble,S M,Griffiths,C,Hall,R E,Hammond,S,Harley,J L,Hart,E A,Heath,P D,Howden,P J,Huckle,E J,Hunt,P J,Hunt,A R,Johnson,C,Johnson,D,Kay,M,Kimberley,A M,King,A,Laird,G K,Langford,C J,Lawlor,S,Leongamornlert,D A,Lloyd,D M,Lloyd,C,Loveland,J E,Lovell,J,Martin,S,Mashreghi-Mohammadi,M,McLaren,S J,McMurray,A,Milne,S,Moore,M J F,Nickerson,T,Palmer,S A,Pearce,A V,Peck,A I,Pelan,S,Phillimore,B,Porter,K M,Rice,C M,Searle,S,Sehra,H K,Shownkeen,R,Skuce,C D,Smith,M,Steward,C A,Sycamore,N,Tester,J,Thomas,D W,Tracey,A,Tromans,A,Tubby,B,Wall,M,Wallis,J M,West,A P,Whitehead,S L,Willey,D L,Wilming,L,Wray,P W,Wright,M W,Young,L,Coulson,A,Durbin,R,Hubbard,T,Sulston,J E,Beck,S,Bentley,D R,Rogers,J,Ross,M T
期刊：Nature影响因子：48.500
时间：2004起止号：2004 Apr 1;428(6982):522-8
doi：10.1038/nature02379

Abstract

Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。