On determining the sensitivity and specificity of a new diagnostic test through comparing its results against a non-gold-standard test

通过将新诊断测试的结果与非金标准测试的结果进行比较,来确定新诊断测试的敏感性和特异性。

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Abstract

Diagnostic tests are important clinical tools. To assess the sensitivity and specificity of a new test, its results should be compared against a gold standard. However, the gold-standard test is not always available. Herein, I show that we can compare the new test against a well-established diagnostic test (not a gold-standard test, but with known sensitivity and specificity) and compute the sensitivity and specificity of the new test if we would have compared it against the gold-standard test. The technique presented is useful for situations where the gold standard is not readily available.

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