Copper-catalyzed sulfonylation of alkenes with CH(3)SSO(3)Na

铜催化烯烃与 CH(3)SSO(3)Na 的磺酰化反应

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Abstract

A successful methodology for the copper-catalyzed dehydrogenated methylsulfonylation of alkenes utilizing CH(3)SSO(3)Na in conjunction with hypervalent iodine reagents was successfully established. This method offers a practical avenue to obtain allyl methyl sulfones and alkenyl methyl sulfones by forming C-S bonds. Using the C-H bond oxidation sulfonylation strategy with alkenes and Bunte salts, we successfully synthesized a total of twenty two compounds, including four examples of deuterium-substituted molecules, and demonstrated one example of a scale-up reaction.

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