Abstract
A solid pseudopapillary neoplasm of the pancreas is a rare tumor accounting for 1-2% of exocrine pancreatic neoplasms and around 5% of cystic pancreatic lesions in adults. It predominantly affects young women and is usually diagnosed incidentally due to its non-specific clinical presentation. Although its exact cause is unclear, it is believed to originate from pluripotent cells of the genital ridges. We report the case of a 26-year-old female patient with an asymptomatic epigastric mass. An magnetic resonance scan revealed a large, heterogeneous lesion in the head of the pancreas, with no evidence of vascular invasion or metastasis. A cephalic duodenopancreatectomy was performed, achieving tumour-free margins with no lymphovascular or perineural involvement. The patient had a favourable postoperative recovery, with no recurrence after three years of follow-up. These neoplasms are diagnosed based on imaging studies, and complete surgical resection is the treatment of choice. Despite their low malignant potential, factors such as tumour size, capsular invasion, and cellular atypia may influence prognosis. This case highlights the importance of treatment in specialized centers to optimize oncological outcomes.