Overexpression of a disintegrin and metalloproteinase 9 (ADAM9) in relation to poor prognosis of patients with oral squamous cell carcinoma

解整合素和金属蛋白酶 9 (ADAM9) 的过度表达与口腔鳞状细胞癌患者预后不良的关系

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作者:Shuangjiang Wu #, Lang Cheng #, Tao Luo, Anupong Makeudom, Lei Wang, Suttichai Krisanaprakornkit

Abstract

This study investigates the expressions of ADAM9, CDCP1 and t-PA in OSCC and their impacts on patient prognosis. Previous research has demonstrated the overexpression of ADAM9 and activation of plasminogen activator in OSCC, but CDCP1's role remains unexplored. While these biomolecules are known to contribute to lung cancer metastasis, their concurrent expressions in OSCC have not been thoroughly examined. Our aim is to assess the expressions of ADAM9, CDCP1, and t-PA in OSCC specimens, compare them with normal oral tissues, and explore their correlation with OSCC's clinicopathological features and patient survival outcomes.

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