Antitumor activity of 5-fluorouracil polymeric nanogel synthesized by gamma radiation on a rat model of colon carcinoma: a proposed mechanism
γ 射线合成的 5-氟尿嘧啶聚合物纳米凝胶对结肠癌大鼠模型的抗肿瘤活性：拟议机制
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作者：Omayma A R Abo-Zaid, Fatma S M Moawed, Wael E M Barakat, Mohamed Mohamady Ghobashy, Esraa S A Ahmed
| 期刊： | Discover Oncology | 影响因子： | 2.800 |
| 时间： | 2023 | 起止号： | 2023 Jul 26;14(1):138. |
| doi： | 10.1007/s12672-023-00733-z | 靶点： | AROS |
| 研究方向： | 肿瘤 | 疾病类型： | 肠癌 |
Conclusion
Collectively, these data might strengthen the therapeutic potential of 5-FU nanogel which can be used as an antitumor product for colon cancer.
Results
5-FU nanogel reduced the levels of the TLR2/ NF-κβ as well as the expression of PI3K/AKT/mTOR. Moreover, it promoted autophagy through the activation of the AMPK and its downstream targets which consequently augmented the intrinsic and extrinsic apoptotic pathways.
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