Abstract
In several studies, regional cerebral oxygen saturation (rSO(2)) has been measured in patients with postcardiac arrest syndrome (PCAS) to analyze the brain's metabolic status. However, the significance of rSO(2) in PCAS patients remains unclear. In the present study, we investigated the relationship between rSO(2) and physiological parameters. Comatose survivors of out-of-hospital PCAS with targeted temperature management (TTM) at 34°C for 24 hours were included. All patients were monitored for their rSO(2) and additional parameters (arterial oxygen saturation [SaO(2)], hemoglobin [Hb], mean arterial pressure [MAP], arterial carbon dioxide pressure [PaCO(2)], and body temperature]) measured at the start of monitoring and 24 and 48 hours after return of spontaneous circulation (ROSC). Patients were divided into favorable and unfavorable groups, and the correlation between rSO(2) and these physiological parameters was evaluated by multiple regression analysis. Forty-nine patients were included in the study, with 15 in the favorable group and 34 in the unfavorable group. There was no significant difference in the rSO(2) value between the two groups at any time point. The multiple regression analysis of the favorable group revealed a moderate correlation between rSO(2) and SaO(2), Hb, and PaCO(2) only at 24 hours (coefficients: 0.482, 0.422, and 0.531, respectively), whereas that of the unfavorable group revealed moderate correlations between rSO(2) and Hb values at all time points, PaCO(2) at 24 hours and MAP at 24 and 48 hours. rSO(2) was moderately correlated to MAP in unfavorable patients. To optimize brain oxygen metabolic balance for PCAS patients with TTM measuring rSO(2), we suggest total evaluation of each parameters of SaO(2), Hb, MAP, and PaCO(2).