At Long Last: The Me(3) Si Group as a Masked Alcohol

终于揭晓:Me(3)Si 基团作为一种掩蔽醇

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Abstract

For a long time, the Me(3) Si group has been ostracized from the family of aryl- and heteroatom-substituted congeners for the difficulties associated with its further chemoselective manipulation into another synthetically useful functional group. A hypervalent iodine reagent has now been shown to do exactly that by electrophilic demethylation. Coupled with the Tamao-Fleming oxidation, the Me(3) Si group becomes a placeholder for a hydroxy group.

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