Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum

青蒿素耐药恶性疟原虫K13螺旋桨基因的新突变

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Abstract

We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012-2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.

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