Nickel-Catalyzed Conversion of Enol Triflates into Alkenyl Halides

镍催化烯醇三氟甲磺酸酯转化为烯基卤化物

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Abstract

A Ni-catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench-stable Ni(OAc)(2) ⋅4 H(2) O as a precatalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either 1,5-cyclooctadiene or 4-(N,N-dimethylamino)pyridine.

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