Abstract
Background: Quantitative magnetic resonance imaging (MRI) techniques such as T(2) mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using mean T(2) values and T(2) distribution profiles after an ultrasound (US)-guided single platelet-rich plasma (PRP) injection. Methods: Twenty-six patients with symptomatic supraspinatus tendinopathy were divided into tendinosis (n = 9) and partial tear (n = 13) groups. T(2) mapping and clinical evaluations (shoulder pain and disability index questionnaire (SPADI), Constant-Murley score) were conducted at baseline and 6 months post-PRP. Mean T(2) values were measured in three tendon segments (lateral, middle, and medial), and T(2) profiles were compared to asymptomatic controls. Results: Clinical outcomes showed significant improvement in both the tendinosis and partial tear groups at the 6-month follow-up. Although no significant changes were observed in the mean T(2) relaxation times across tendon segments following PRP treatment, T(2) distribution profiling revealed statistically significant alterations in both groups. In the tendinosis group, post-treatment T(2) profiles approached those of the asymptomatic controls, suggesting structural remodeling consistent with tendon healing. Conclusions:T(2) mapping is an effective tool for detecting tendon remodeling following PRP therapy. Structural improvements indicative of tissue healing were observed in cases of tendinosis, but not in partial tendon tears. These findings support the use of T(2) mapping-particularly the T(2) distribution profiling-as a quantitative biomarker for assessing treatment response to PRP.