Ligand Postsynthetic Functionalization with Fluorinated Boranes and Implications in Hydrogenation Catalysis

利用氟化硼烷对配体进行后合成功能化及其在氢化催化中的应用

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Abstract

The incorporation of boron functionalities into transition-metal catalysts has become a promising strategy to improve catalytic performance, although their synthesis typically entails the preparation of sophisticated bifunctional ligands. We report here the facile and direct postsynthetic functionalization of rhodium(I) compound [(η(5)-C(9)H(7))Rh(PPh(3))(2)] (1) by treatment with perfluorinated boranes. Borane addition to 1 results in an unusual C(sp(2))-H hydride migration from the indenyl ligand to the metal with the concomitant formation of a C-B bond. In the case of Piers' borane [HB(C(6)F(5))(2)], this is followed by a subsequent hydride migration that leads to an unprecedented 1,2-hydrogen shift reminiscent of Milstein's cooperative dearomatization pathways. Computational investigations provide a mechanistic picture for the successive hydride-migration steps, which enriches the non-innocent chemistry of widespread indenyl ligands. Moreover, we demonstrate that the addition of Piers' borane is highly beneficial for catalysis, increasing catalyst efficiency up to 3 orders of magnitude.

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