Abstract
Peroxyzymes simply use H(2)O(2) as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H(2)O(2) can be addressed by a controlled supply of H(2)O(2), ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H(2)O(2) generation. Very promising turnover numbers for the biocatalysts of up to 318 000 have been achieved.