Abstract
The pineal gland is a neuroendocrine gland closely related to human aging. Melatonin is a kind of indole neuroendocrine hormone secreted by the pineal gland, which is essential for maintaining physiological function. Many researches found that melatonin plays a key role in anti-aging-related cardiovascular diseases. In this paper, the latest advances in the study of melatonin and aging-related cardiovascular diseases are reviewed, and their related physiological functions and mechanisms are discussed.