Candidate cancer-targeting agents identified by expression-profiling arrays

通过表达谱分析阵列鉴定的候选癌症靶向药物

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作者:Vittavat Termglinchan, Wachiraporn Wanichnopparat, Kulachanya Suwanwongse, Chunhakarn Teeyapant, Kanticha Chatpermporn, Kanchana Leerunyakul, Khwanruthai Chuadpia, Onpailin Sirimaneethum, Parinya Wijitworawong, Wattanakitch Mutirangura, Chatchawit Aporntewan, Chanida Vinayanuwattikun, Apiwat Mutiran

Background

One particularly promising component of personalized medicine in cancer treatment is targeted therapy, which aims to maximize therapeutic efficacy while minimizing toxicity. However, the number of approved targeted agents remains limited. Expression microarray data for different types of cancer are resources to identify genes that were upregulated. The genes are candidate targets for cancer-targeting agents for future anticancer research and targeted treatments.

Conclusion

This research demonstrates a clinical correlation between bioinformatics data and currently approved treatments and suggests novel uses for known protein inhibitors in future antineoplastic research and targeted therapies.

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