Abstract
We present a case series comprising three patients with concomitant septic arthritis of the knee and osteomyelitis of the femur. Early advanced imaging rendered the accurate diagnosis of the condition and the appropriate surgical approach and technique used to treat the infection. Repeated extensive surgical debridement, irrigation and insertion of antibiotic-impregnated cement rod into the femur were required, in addition to long term antibiotics. The infection in all three cases was eradicated successfully. Following a period of physical rehabilitation, they had fairly preserved independent ambulatory function. We advocate a high index of suspicion of this condition with subsequent early advanced imaging for a timely diagnosis. In addition, we described our challenges in the fabrication process of the antibiotic-impregnated cement rod.