Conclusion
Results from the pilot studies suggest that PEDF is useful biomarker for pancreatic cancer.
Methods
Soluble OPG and PEDF were measured from human pancreatic cancer patients by ELISA.
Objective
To study if the soluble Osteoprotegerin (OPG) and pigment-epithelial derived factor (PEDF) levels in serum will be an indicator of cancer progression.
Results
We show that while OPG has been less predictive features, PEDF is more sensitive than CA19-9 in cancer detection. More importantly, PEDF and CA19-9 as combined markers showed higher sensitivity in stratifying early stages of pancreatic cancer.