Abstract
Malignant glioma is an aggressive disease and there is no effective therapy. Recently, with the elucidation of mechanisms for glioma formation and progression, the critical molecules involved in the process are considered as therapeutic targets and numerous of drugs against these targets are ongoing for evaluation in clinic trail. FoxM1 has been recognized as one of the common pathways in cancer cells including glioma cells. FoxM1 signal network is reported to be critical in glioma by promoting cell proliferation, invasion, angiogenesis and cancer stem cell self-renewal. FoxM1 may represent a novel therapeutic target and FoxM1 inhibitors may provide a new therapeutic strategy against glioma.