Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse

使用 IgMi 小鼠研究 B 细胞和抗体在鼠鞭虫感染过程中的重要性

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作者:Rinal Sahputra, Emma A Murphy, Ruth Forman, Iris Mair, Muhammad Z H Fadlullah, Ari Waisman, Werner Muller, Kathryn J Else

Key messages

During a high-dose T. muris infection, B cells are important in maintaining the Th1/Th2 balance in the MLN through an antibody-independent mechanism. High levels of IL-10 in the MLN early post-infection, and the presence of IL-10-producing B cells, correlates with susceptibility to T. muris infection. B cells maintain gut homeostasis during chronic T. muris infection via an antibody-dependent mechanism.

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